We're hiring!

Join FinalDose

Build the DNA-triggered cancer cure. Small team, hard problems, real wet-lab loop.

REQ-01/LondonOpen

Operations — Biology

As FinalDose's first Lab & CRO Operations Manager, you will build our laboratory from the ground up while simultaneously managing relationships with our China-based CRO partners. In the early stages, the role will be weighted toward lab buildout and internal operations; as the lab matures, the balance will shift toward CRO oversight and external study management. This dual mandate makes you the operational backbone of the company — your work directly determines how quickly and reliably we advance our preclinical pipeline, both in-house and through external partners.

Responsibilities

  • Lead full lab buildout including equipment procurement, facility layout, and safety compliance
  • Manage reagents, consumables, and inventory across multiple concurrent programs
  • Establish and maintain SOPs for all laboratory operations
  • Oversee equipment maintenance, calibration, and service contracts
  • Manage vendor relationships, procurement, budgeting, and shipping/receiving logistics
  • Ensure biosafety and institutional compliance (BSL-2)
  • Manage day-to-day relationships with China-based CRO partners across cell biology, animal model, biodistribution, and toxicology studies
  • Provide quality oversight to ensure outsourced studies meet protocol specifications, timelines, and data integrity standards
  • Coordinate sample shipment, data transfer, and reporting between CROs and the core science team
  • Support vendor evaluation, selection, and contract negotiation for new CRO engagements
  • Track CRO budgets and flag variances proactively

Required

  • M.S. or Ph.D. in biology, biochemistry, pharmacology, or a related life science field
  • 3–5+ years of experience managing a molecular and/or cell biology laboratory
  • Demonstrated experience with lab setup or buildout
  • Working knowledge of BSL-2 operations, mammalian cell culture workflows, animal model workflows, and standard molecular biology equipment
  • Experience managing CRO or external vendor relationships, preferably with China-based partners
  • Fluent in Mandarin and English (written and spoken)
  • Proven ability to manage multiple concurrent projects with strong organizational skills
  • Experience with procurement, budgeting, and vendor negotiation

Preferred

  • Prior experience in a start-up or early-stage biotech environment
  • Experience overseeing preclinical animal studies at Chinese CROs
  • Familiarity with gene therapy or gene editing preclinical programs
  • Awareness of NMPA regulatory requirements
  • Experience bridging US/Australia–China biotech operations
  • Working knowledge of GLP standards and study monitoring practices
Applyfounders@finaldose.ai
REQ-02/LondonOpen

Biology — Delivery

FinalDose's platform requires delivery solutions tailored to each therapeutic indication. You will lead delivery engineering across multiple administration routes, optimizing lipid nanoparticle formulations for tissue-specific targeting and therapeutic efficacy. Your work will bridge in vitro formulation development with in vivo validation and ultimately support technology transfer for GMP manufacturing. This is a critical role linking our construct engineering with clinical-stage drug products.

Responsibilities

  • Lead LNP delivery engineering across multiple administration routes, including local, systemic, and inhaled formulations
  • Develop and optimize LNP formulations with full physicochemical characterization (DLS, encapsulation efficiency, zeta potential)
  • Perform in vitro delivery optimization and hand off validated formulations to the in vivo team for animal studies
  • Support CMO/CDMO selection and technology transfer for GMP-grade manufacturing
  • Collaborate with biology teams to evaluate delivery efficiency using functional readouts (editing efficiency, reporter assays) in cell lines and primary cells

Required

  • Ph.D. in pharmaceutical sciences, drug delivery, biomedical engineering, or chemical engineering
  • 3–5+ years of hands-on experience with lipid nanoparticle formulation
  • Demonstrated expertise in at least two of the following: mRNA-LNP encapsulation and delivery, tissue-targeted delivery (SORT technology or ionizable lipid screening), inhaled or pulmonary drug delivery
  • Experience with microfluidic mixing and formulation scale-up
  • In vitro delivery characterization in cell lines and primary cells

Preferred

  • Experience with intravesical or local drug delivery
  • CMC or technology transfer experience with a CDMO
  • Air-liquid interface (ALI) culture and aerosol delivery expertise
  • Awareness of GMP manufacturing processes and requirements
Applyfounders@finaldose.ai